This item is in: Materials > Biomaterials > Materials
Hyaluronan: Proceedings of an international meeting, September 2000, North East Wales Institute, UKEdited by J F Kennedy, University of Birmingham, G O Phillips, Phillips Hydrocolloid Research Ltd, P A Williams, North East Wales Institute of Higher Education, UK and Guest editor V C Hascall, Lerner Research Institute, USA
- outlines the proceedings of the landmark conference which focused on key developments and applications in the use of hyaluronan in tissue repair and reconstruction, among other uses
- the entire range of hyaluronan processes is dealt with in depth by more than 135 individual papers presented in two volumes
- covers analytical chemistry, chemical modification, physical characterisation, cell biology and medical applications
Hyaluronan and its derivatives has developed very quickly in the last few years from a scientific novelty into an important new material for a diverse range of medical and biomaterial applications. This landmark conference focused on developments and applications in the use of hyaluronan in tissue repair and reconstruction, drug delivery systems, anti-cancer treatments and joint recovery and engineering.
The entire range of hyaluronan progress is covered in depth by the more than 135 individual papers:
Analytical chemistry
Structural elucidation and basic chemistry
Electron microscopy and atomic force microscopy
Production, purification and characterisation
Quality in production systems
Chemical modification
Derivatives and properties
Cross-linking
Free radical modification
Physical characterisation
Rheology
Aggregation phenomena
Interaction with water and solution properties
Cell biology
Control and regulation of HA synthases
Cell surface chemistry
HA cell receptors and cell signalling
Interaction with proteins and other biological ligands
Biophysical aspects
Effects on pain receptors
Neurobiology
Role in organisation of extracellular matrix
Role in development (embryogenesis): cell movement/migration
Medical applications
Uses in cartilage and wound repair
Inflammation
Wound regenerative healing
Surgery and tissue engineering
Viscosupplementation / osteoarthritis
Viscoaugmentation and viscoprotection
Anti-adhesion applications
Brug delivery systems
Binding onto tumour cells and metastases
ISBN 1 85573 570 9
ISBN-13: 978 1 85573 570 5
October 2002
1152 pages 244 x 172mm hardback
£445.00 / US$755.00 / €535.00
Usually dispatched within 24 hours
About the editors
John Kennedy is Director of the Birmingham Carbohydrate and Protein Tehcnology Group, School of Chemistry, University of Birmingham. He is Director of Chembiotech laboratories and is also Professor of Applied Chemistry at The North East Wales Institute of higher Education (NEWI). He is a Fellow of the Royal Society of Chemistry, the Institute of Management, the Institute of Food Science and Technology and the Institute of Biology. He is also editor of the journal, Carbohydrate Polymers.
Glyn Philips is Chairman of Research Transfer Ltd and a consultant to numerous industrial companies and associations. Formerly Professor in the Department of Chemistry and Applied Chemistry at the University of Salford and Executive Principal of The North East Wales Institute of Higher Education, he is now Chairman of the Food Hydrocolloids Trust and of the Cellucon Trust.
Peter Williams is Head of the Multidisciplinary Research and Innovation Centre and the Centre of Expertise in Water Soluble Polymers, and Professor of Polymer and Colloid Chemistry at The North East Wales Institute of Higher Education.
Titles which may also be of interest:
Cellulose and cellulose derivatives
Cellulosic pulps, fibres and materials
Regenerated cellulose fibres
The chemistry and processing of wood and plant fibrous material
Contents
PART 1 OVERVIEW OF THE HISTORY AND DEVELOPMENT OF HYALURONAN
PART 2 CHARACTERISATION AND SOLUTION PROPERTIES OF HYALURONAN
PART 3 RHEOLOGICAL BEHAVIOUR OF HYALURONAN
PART 4 BIOSYNTHESIS AND BIOLOGICAL DEGRADATION OF HYALURONAN
PART 5 NOVEL MODIFIED FORMS OF HYALURONAN
PART 6 CELL SURFACES AND HYALURONAN RECEPTORS
PART 7 THE ACTION OF HYALURONAN IN CELLS
PART 8 KERATINOCYTES AND HYALURONAN
PART 9 ADHESION FORMATION AND HYALURONAN
PART 10 APPLICATION OF HYALURONAN IN TISSUE ENGINEERING
PART 11 THE FUNCTION AND USE OF HYALURONAN IN WOUND HEALING
PART 12 THE ROLE OF HYALURONAN IN TISSUES
PART 13 THE USE OF HYALURONAN IN DRUG DELIVERY
PART 14 ASPECTS OF HYALURONAN IN JOINTS
PART 15 CLINICAL APPLICATIONS OF HYALURONAN
PART 1 OVERVIEW OF THE HISTORY AND DEVELOPMENT OF HYALURONAN
Hyaluronan before 2000
T C Laurent
Karl Meyer — Discoverer of hyaluronan
Karl Meyer
Alexander G ("Sandy") Ogston 1911-1996
Albert Dorfman
PART 2 CHARACTERISATION AND SOLUTION PROPERTIES OF HYALURONAN
Predictive and experimental behaviour of hyaluronan in solution and solid state
K Haxaire, E Buhler, M Milas, S Perez and M Rinaudo
Aqueous SEC, light scattering and viscometry of ultra – high molar mass hyaluronan
R Mendichi and A G Schieroni
Molecular characterisation of hyaluronan and hylan using GPC-Malls and asymmetrical flow FFF-MALLS
S Al-Assaff, P A Williams and G O Phillips
The intrinsic viscosity of hyaluronan
M K Cowman and S Matsuoka
Viscosity of polymer solutions revisited
S Matsuoka and M K Cowman
Conformational and rheological properties of hyaluronan
K Nishinari, Y Mo, R Takahashi, K Kubota and.A Okamoto
The heat dependence of hyaluronan conformation
G Armand, K Fan and E A. Balazs
Temperature effect on the dynamic rheological characteristics of hyaluronan, hylan A and Synvisc
J M Hoefling, M K. Cowman, S Matsuoka and E Balazs
Tapping mode atomic force microscopy of hyaluronan and hylan A
M K Cowman, M Li, A Dyal and S Kanai
Biological properties of hyaluronan are controlled and sequestered by tertiary structures
J E Scott and F Heatley
Analysis of the concentrated solution properties of hyaluronan by confocal-FRAP show no evidence of chain-chain association
T Hardingham,B C Heng and P Gribbon
Hyaluronic acid self-association in the presence and absence of salts
T M McIntire and D A Brant
Comparison of the reactivity of different reactive oxidative species (ROS) towards hyaluronan
B J Parsons, S Al-Assaf, S Navaratnam and G O Phillips
Polysaccharide fragmentation induced by hydroxyl radicals and hypochlorite
M D Rees, C L Hawkins and M J Davies
Getting to grips with HA-protein interactions
C.D Blundell, J D Kahmann, A Perczel, D J Mahoney, M R Cordell, P Teriete,I D Campbell and A J Day
PART 3 RHEOLOGICAL BEHAVIOUR OF HYALURONAN
Effect of metal ions on the rheological flow profiles of hyaluronate solutions
C.J Knill, Y Latif and J F Kennedy
Rheological behaviour of hyaluronan, healon and hylan in aqueous solutions
M Milas, M Rinaudo, I Roure, S Al-Assaf, G O Phillips and P A Williams
Rheological creep experiments utilizing mixtures of 1% hylan A solution and 0.5% hylan B gel slurry
J .M Hoefling, S Matsuoka and E Balazs
Rheology of hyaluronan products
O Wik, B Agerup and H B Wik
Structural change in hydrogelation of hyaluronan induced by annealing the solution in sol state
M Takahashi, T Iseki, H Hattori, T Hatakeyama and H Hatakeyama
The roles of extensional and shear flows of synovial fluid and replacement systems in joint protection
C Backus, S P Carrington, L R Fisher, J A Odell and D A Rodigues
PART 4 BIOSYNTHESIS AND BIOLOGICAL DEGRADATION OF HYALURONAN
The production of hyaluronic acid from streptococci
D C Ellwood
Hyaluronan synthases mechanistic studies and biotechnological applications
Paul L DeAngelis
In vivo investigation of hyaluronan synthase function during vertebrate embryogenesis
J Y lee and A P Spicer
Influence of substrate and enzyme concentrations on hyaluronan hydrolysis kinetics catalysed by hyaluronidase
T Asteriou, B Deschrevel, F Gouley, and J C Vincent
PART 5 NOVEL MODIFIED FORMS OF HYALURONAN
Hyaluronan linear and crosslinked derivatives as potential/actual biomaterials
V Crescenzi, A Francescangeli, D Renier and D Bellini
Novel biomaterials based on cross-linked hyaluronan structural investigations
L Michielin, C Bevilacque, S Paoletti, A Gamini R Toffanin and F Micali..
A novel crosslinking process for hyaluronan
X Zhao, J Fraser and C Alexander
Derivatized hyaluronan for gels and nanochemically patterned surfaces
R.Barbucci, D Pasqui and G Leone
Hyaluronan DNA matrix for gene transfer
W.Chen, D Checkla and P Dehayza
Thermal properties of hyaluronic acid-based polyurethane derivates associated with water
H Hatakeyama, Y Asano, T Hatakeyama and J F Kennedy
Phase transition of sodium hyaluronate ,hylan and polyurethanes derived from hyaluronic acid in the presence of water
T Hatakeyama and H Hatakeyama
PART 6 CELL SURFACES AND HYALURONAN RECEPTORS
CD 44 The link between hyaluronan and the cytoskeleton
C.B Knudson, G A Nofal, G Chow and R S Peterson
Hyaluronan binding by cell surface CD44
J Lesley, N English, V C Hascall, M Tammi and R Hyman
Inhibition of tumor growth in vivo and anchorage-independent growth in vitro by perturbing hyaluronan-cell interactions
B P Toole, R M Peterson and S Ghatak
Novel Endothelial Hyaluronan Receptors
D G Jackson, R Prevo, J Ni and S Banerji
An insight into cellular signalling mediated by hyaluronan binding protein (HABP1)
T B Deb, M Majumdar, A Bharadwaj, B.K Jha and K Datta
RHAMM (CD168) co-associates with and regulates er kinase
R Harrison, F S Wang and E A Turley
Poly I:C induces mononuclear leukocyte –adhesive hyaluronan structure on colon smooth muscle cells I and versican facilitate adhesion
C A de la Motte, V C Hascall, J A Drazba and S A Strong
The generation of hyaluronan-dependent pericellular matrix in vitro
J R E Fraser
Purification and characterization of the hyaluronan receptor for endocytosis (HARE)
P H Weigel, C Mcgary, B Zhou and J Weigel
Identification of hyaluronan as crystal binding molecule at the surface of migrating and proliferating MDCK cells
C.F Verkoelen, B g vd Boom, M S J Schepers and J C Romijn
PART 7 THE ACTION OF HYALURONAN IN CELLS
Anti-cancer activity of hyaluronan
M C Filion, S Menard, B Filion, J Roy, S Reader and N C Phillips
Pro-inflammatory activity of contaminating DNA in hyaluronan preparations
M C Filion and N C Phillips
Effect of Hyaluronan Oligosaccharides on the expression of heat shock protein72
H Xu, T Ito, A Tawada, H Maeda, H Yamanokuchi, K Isahara, K Yoshida, Y Uchiyama and A Asari
The impact of hyaluronan on the in vitro invasive properties of human breast cancer cell lines with CD44 expression
A Herrera-Gayol and S Jothy
Identification of a novel intracellular hyaluronan-binding protein
S Matsuoka and M K Cowman
The presence and processing of intercellular hyaluronan in proliferating cells
S P Evanko and T N Wight
Low molecular weight oligosaccharides of hyaluronan potently activate dendritic cells
C C Termeer, P Prehm and J C Simon
Signal transduction pathways in hyaluronan induced proliferation of endothelial cells
M Slevin, S Kumar and J Gaffney
Control of hyaluronan (HA) generation in renal proximal tubular epithelial cells
G Stuart , S Jones, M Jones and A O Phillips
Mechanical injury of human peritoneal mesothelial cells (HPMC) is accompanied by an increase in hyaluronan synthesis
S Yung , G J Thomas and M Davies
Apodtosis and hyaluronan-enriched extracellular matrix degradation in cumulus cell-oocyte complex: implication in fertility
M d Giacomo, A Camaioni and A Salustri
Proteoglycan enhances the formation of the SHAP-Hyaluronan complex and its effect in hyaluronan-rich matrix
M Zhao, M Yoneda, L Zhuo, L Huang, H Watanabe, Y Yamada, S Nagasawa,H Nishimura and K Kimata
Enhanced thromboxane synthesis through the induction of cyclo- oxygenase-2 by hyaluronan in renal cells
L K Sun
PART 8 KERATINOCYTES AND HYALURONAN
Hyaluronan metabolism and distribution in stratified differentiated cultures of epidermal keratinocytes
S Pasonen-Seppanen, R Tammi, M Tammi, M Hogg V C Hascall, and D K MacCallum
Intracellular Hyaluronan in epidermal keratinocytes
R Tammi, K Rilla, J P Piemimaki, M Hogg, D K MacCallum, V C Hascalland M Tammi
Evaluation of the influence of hyaluronan and hyaluronan fragments on human keratinocytes during UV irradiation
D Gerlach, C Huschka and W Wohlrab
Effect of hyaluronan on matrix metalloprotease expression in fibroblasts and keratocytes
N Isnard, J.M.Legeais, G Renard and L Robert
Aging and regulation of hyaluronan biosynthesis comparative studies on human skin fibroblasts and corneal keratocytes
L Robert, I Fodil, N Isnard, F Dupuy, A Robert and G Renard
Effects of KGF and TGF-B on Hyaluronan synthesis and distribution in extra-, peri-, and intracellular compartments of epidermal keratinocytes
S Karvinen, M Tammi and R Tammi
Hyaluronan stimulates keratinocyte migration and activates the transcription factor AP-1 in keratinocytes through the JNK pathway
K Torronen, Myabal, K Rilla, K Karrniranta, R Tammi, M. J. Lammi
Hyaluronan synthase 2 (HAS2) regulates migration of epidermal keratinocytes
K Rilla, m Lammi, R Sironen, V C Hascall, R Midura, M Tammi and R Tammi
EGF regulates HAS2 expression, controls epidermal thickness and stimulates keratinocyte migration
M Tammi, J P Pienimaki, k Rilla, C Fulop. M J Lammi, R Sironen, R Midura, V C Hascall, M Luukkonen, K Torronen, T Lehto and R Tammi
PART 9 ADHESION FORMATION AND HYALURONAN
Viscoseparation a historical perspective
Biomatrix,inc
Dry film made of hylan to prevent adhesion between two healing tissue surfaces
EA Balazs, N E Larsen, E A Leshchiner, J D Boney, V Mitliski , E G Parentand J L Whestone
Adhesion prevention effects of tolmetin combined with hyaluronic acid
S Wang, P Ling, Y He, T Zhang
Preclinical animal studies on incert adhesion r prevention gel
D M Wiseman, C H Sherwood, KK Sadozai and P C Bulpitt.
Biocompatible gel of hyaluronan (2) medical applications
T Miysohi and A Okamoto
Cell adhesion on crosslinked hyaluronan surfaces
M Witt, M Gelinsky, R Mai, K Flade, C Rohlecke, e Schulze R H W Funk and W Pompe
Cell attachment and growth on solid hyaluronan (hylan B gel)
E A Balazs, I K Eliezer-Pye, R A Dennebaum, N E Larsen and J L Whetstone
PART 10 APPLICATION OF HYALURONAN IN TISSUE ENGINEERING
Viscoaugmentation a historical perspective
Biomatrix inc
Hyaluronan and tissue engineering
L A Solchaga, V M Goldberg and A I Caplan
Hyaluronan is the organizational scaffold of the interphotoreceptor matrix of the retina
J G Hollyfield, M E Rayborn, P des Senanayake and A Calababro
Cartilage repair with bone marrow in a hyaluronan based scaffold
L A Solchage, V M Goldberg and A I Caplan
Potential use of novel hyaluronan – based delivery vehicle in bone regeneration
L A Solchage, and A I Caplan
A novel hyaluronan biomaterial (Hyaff – 11) as scaffold for chondrocytes and bone marrow stormal cells
A Facchini, A Piacentini, M Fiorni, L Scorzoni, B Grigolo, G Lisignoli, P Gobbi,G Mazzotti,M Duca,A Pavesio
Hyaluronan based dermal and epidermal grafts in the treatment of diabetic foot ulcers
C Caravaggi, E Faglia, L d Paola, G Clerici, R D Giglio, E Sommariva, C Pritelli, M Mantero, M Caminiti, V Curciand P Frantino
Soft tissue reconstruction in severely traumatized patients using hyaluronan based dermal and epidermal grafts
D A Hollander, S Kramer, M Y Hakimi and J Windolf
Hyaluronan scaffolds for adipose tissue reconstruction
D von Heimburg, and N Pallua
Induction of chondro and osteo-genesis by implanted collagen hyaluronan biomatrix with GDF-5
C K Ng, R Daverman, A Merck, A Thompson, L S Liu, M A Heidaran and R C Spiro
PART 11 THE FUNCTION AND USE OF HYALURONAN IN WOUND HEALING
Viscoprotection a historical perspective
Biomatrix Inc
The use of ophthalmic viscosurgical devices in cataract surgery
S A Arshinoff
Therapeutic effect of 1% Na Hyaluronan on corneal wound healing
J H Chung
Chronic wound healing and inflammation
K Moore
Functions of hyaluronan in wound repair
W Y J Chen
The role of pericellular matrix formation during wound healing in renal stone disease
M S J Schepers, B G vd Boom and C F Verkoelen
PART 12 THE ROLE OF HYALURONAN IN TISSUES
Is hyaluronan degradation an angiogenic/metastic switch?
D C West and H Chen
Hyaluronan is a critical component in atherosclerosis and restenosis and in determining arterial smooth muscle cell phenotype
T N Wight and S p Evanko
Disruption of hyaluronan synthase – 2 abrogates normal cardiac morphongenisis and hyaluronan mediated transformation of epithelium to mesenchyme
T D Camenisch, A P Spicer, T Brehm-Gibson, J Beisterfeldt. M L Augustine, A Calabro jr., S Kubalak, S E Klewer and J A McDonald
Transcriptional regulation of Hyal-2 hyaluronidase by De Novo methylation of CpG islands in brain
G Lepperdinger, B Strobl, J Mullegger and G Kreil
Separate regulation of hyaluronan in the kidney cortex and medulla
B Flamion, P Boel, R A Kramp and J M Strijthagen
Hyaluronan during lever regeneration after partial hepatectomy transient accumulation in the tissue and elevation of the serum concentration
T Yada, H Maeda, Y Sakura and K Kimata
Intratracheal instillation of lipopolysaccharide in mice results in increased hyaluronan deposition in the lung
J h J Vernooy, M A Dentener, W A Buurman and E F M Wouters
The degradation of hyaluronan during periodontal diseases a potential role for reactive oxygen species
R Moseley, R J Waddington and G Embery
Effect of ventilation on hyaluronan produced in the pleural space of rabbits switch
P M Wang and S J Lai-Fook.
What is the role of hyaluronan in the umbilical cord
M Meaney and O Wiebkin
PART 13 THE USE OF HYALURONAN IN DRUG DELIVERY
The use of hyaluronan in topical drug delivery
M B Brown, B Forbes, M Hanpanitcharoen and G P Martin
Preparation of hyaluronan gel and the application to drug delivery
I Kaetsu, K Sutani, K Uchida, G O Phillips, H Matsumura and Y Matsubara
Hyaluronic acid hydrogel film a new biomaterial for drug delivery and wound healing
Y Luo, K R Kirker and G D Prestwich
Hyaluronan biomaterials for targeted drug delivery and wound healing
G D Prestwich, Y Luo, K r Kirker, M r Ziebell and J Shelley
The use of hyaluronan and hylans for skin care a historical perspective
Biomatrix inc.
PART 14 ASPECTS OF HYALURONAN IN JOINTS
Synthesis and degradation of hyaluronan in articular cartilage
C R Flannery, D R R Hiscock and B Caterson
Hyaluronan synthesis in human articular cartilage
M T Bayliss and J Dudhia
Mechanomodulatory influences upon HA production in joint development and maintenance
O A C Kavanagh, E Lamb, K j Dowthwaite, G archer and A Pitsillides
Mutually exclusive distribution of link protein and hyaluronectin during cartilage morphogenesis a role for free hyaluronan
P Rooney, N Girard, B Delpech, J Pointing and S Kumar
Maintenance of cartilage extracellular matrix the participation of HAS-2 and CD 44
W Knudosn, Y Nishida and R S Peterson
Secretory regulation in vivo molecular reflection and hydraulic roles of synovial hyaluronan
J R Levick, P J Coleman and R M Mason
Ultrastructural evidence for extracellular matrix disorganisation following matrix disorganisation following specific removal of hyaluronan from synovium
P J Coleman
Mechanoprotective actions of elastoviscous hylans on articular pain receptors
M Pawlak, A Gomis, S Just, B Heppelmann, C Belmonte and R F Scmidt
Effect of joint tissues of intra-articular treatment with 500-730 kDa hyaluronan insight into the mechanism of action
D Guidolin and L Frizziero
Effects of intra - articular injection of hyaluronan on papain- induced hydrarthrosis of knee in rabbits
S Matsuzaka, S Miyauchi and K Horie
Control of hyaluronan secretion into joint fluid in vivo: Role of protein Kinase C (PKC)
C L Anggiansah, D Scott, A Poli, P J Coleman, J James, A Houston, R M Mason and J M Levick
Hyaluronan metabolism in response to mechanical strain is modulated by matrix depletion
G P Dowthaite, S Thomas, C R Flannery, A A Pitsillides and C W Archer
Viscosupplementation a historical perspective
Biomatrix, Inc.
The availability of highly elastoviscous hylan for viscosupplementation can delay knee replacement in patients with advanced osteoarthritis
C Weiss, D Waddell and E Miller
Clinical evaluation of hyaluronic acid combined with tolmetin in the treatment of osteoarthritis of the knee
S Wang, Y he, P ling and T Zhang
Effects of hyaluronan on chronic arthritis model in rabbit
S Gotoh, K Takahashi, J Onaya, K Okamura, K Horie
Effects of Elastoviscous solutions of hyaluronan derivatives on mechanotransduction
E de la Pena, S Sala, R F Schmidt and C Belmonte
Effects of hyaluronan on equine articular tissue metabolism
S P Frean and P Lees
PART 15 CLINICAL APPLICATIONS OF HYALURONAN
Molecular strategies for the therapeutic utilization of hyaluronan
P A Band
The question of immunogenicity of hylans
N E Larsen, D f Mess and J L Denlinger
Clinical application of serum hyaluronan for liver diseases and its significance
T Ueno, O Hashimoto, S Tamaki, T Ogata, T Nakamura, R Sakata, K Tanikawa and M Sata
Effects of hyaluronan used as a supplement in peritoneal dialysis solutions
A Brevorowicz, J B Moberly, K pawlaczyk, A Polubinska, M Kuzlan-Pawlaczyk, K Wiecorowska-Tobis, K Ogle, L Martis and D G Oreopoulos
Viscosurgery a historical perspective
Biomatrix Inc
Hyaluronan and hylan in the treatment of osteoarthritis
C Weiss
The control of adhesions with hylan polymers
C Weiss
Hyaluronan derivatives in postsurgical adhesion prevention
D Pressato, E Bigon, M Dona, A Pavesio, D Renier, L Bonafini, P A De Iaco and Mise
Effect on joint tissues of intra-articular treatment with 500-730 kDa hyaluronan insight into the mechanism of action
D Guidolin and L Frizziero
Hyaluronan in the treatment of ankle chondropathy
M Toffolo
Inhibition assay methods for the determination of HA using hyaluronan binding protein and their clinical application
H Maeda, H Fujita and Y Sakura