This item is in: Materials > Biomaterials > Technologies and performance
Biosensors for medical applicationsEdited by S Higson, Cranfield University, UK
Woodhead Publishing Series in Biomaterials No. 45
- provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications
- examines key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors
- reviews biosensors for DNA and RNA detection and characterisation, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors
Biomedical sensors are an essential tool in the detection and monitoring of a wide range of medical conditions from cancer to Parkinson’s disease. Biosensors for medical applications provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications.
Part one focuses on key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors. Impedence interrogated affinity biosensors for medical applications and practical applications of enzyme biosensors are explored, before part two goes on to review specific medical applications. Biosensors for DNA and RNA detection and characterization, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors are investigated, along with biosensors for drug testing and discovery, non-invasive measurements, and wearable biosensors for medical applications.
With its distinguished editor and international team of expert contributors, Biosensors for medical applications is an essential guide for all those involved in the research, design, production and use of medical biosensors.
ISBN 1 84569 935 1
ISBN-13: 978 1 84569 935 2
August 2012
360 pages 234 x 156mm hardback
£135.00 / US$230.00 / €160.00
Usually dispatched within 24 hours
About the editor
Seamus Higson is Professor of Bio- and Electro-analysis and Commercial Director of Cranfield Health at Cranfield University, UK. A member of the UK Engineering and Physical Sciences Research Council (EPSRC), Professor Higson serves in an advisory and/or consultative capacity for a number of public bodies, and has written extensively on a wide range of topics within the fields of medicine, biotechnology, materials science and health.
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Contents
PART 1 PRINCIPLES AND TRANSDUCTION APPROACHES
PART 2 APPLICATIONS OF MEDICAL BIOSENSORS
PART 1 PRINCIPLES AND TRANSDUCTION APPROACHES
Electrochemical biosensors for medical applications
A J Veloso, X R Cheng and K Kerman, University of Toronto Scarborough, Canada
- Introduction to electrochemical sensors
- Electrochemical biosensing applications
- Label–free approaches to electrochemical sensors
- Conclusion and future trends
- References
Piezoelectric biosensors for medical applications
S Tombelli, University of Florence,, Italy
- Introduction
- Piezoelectric immunosensors
- Piezoelectric genosensors
- Piezoelectric biosensors with bio-mimetic receptors
- Conclusions and future trends
- References
Nano-sized biosensors for medical applications
J C Claussen, J Shi, Chandra S Rout, M S Artiles, M M Wickner, M C Stensberg, D Marshall Porterfield and T S Fisher, Purdue University, USA
- Introduction
- Sensing modalities
- Nanomaterial properties
- Biosensors on the nanoscale
- Conclusions
- References
Impedence interrogated affinity biosensors for medical applications: novel targets and mechanistic studies
P A Millner, R L Caygill, D J R Conroy and M A Shahidan, University of Leeds, UK
- Small molecule binding
- Supramolecular structures
- Electrochemical biosensor for clinical diagnostics
- Challenges of carbohydrate sensing
- Bioreceptors for carbohydrate sensing
- Enzymes that act on carbohydrates
- Impedimetric glucose biosensors
- Impedimetric bacterial and viral immunosensors
- Impedance and pathogens
- Bioreceptors used in impedimetric pathogenic biosensor construction
- Detection of exposure to infection
- Conclusion
- Sources of further information and advice
- References
Practical applications and protocols for enzyme biosensors
F Davis and S P J Higson, Cranfield University, UK
- Introduction
- Methods and approaches for using biosensors
- Protocols for enzyme biosensors
- Problems arising from the construction and use of biosensors
- References
PART 2 APPLICATIONS OF MEDICAL BIOSENSORS
Biosensors for DNA and RNA detection and characterization
F Davis and S P J Higson, Cranfield University, UK
- Introduction to nucleic acids and base pairing
- Principles of DNA/RNA sensing
- Electrochemical DNA sensing
- Optical DNA sensing
- Quartz crystal microbalance and surface acoustic wave sensors
- Microcantilever oligonucleotide sensors
- Conclusions
- References
Biosensors for disease biomarker detection
B J Battersby, A Chen, D Kozak and M Trau, The University of Queensland, Australia
- Introduction
- Disease biomarkers
- Established technologies for disease biomarker detection
- Proteins at surfaces
- Emerging technologies for disease biomarker detection
- Future trends
- Sources of further information and advice
- References
Affibodies as an alternative to antibodies in biosensors for cancer markers
M D Harris, Cranfield University, UK S Tombelli and G Marazza, Università degli Studi di Firenze, University of Florence, Italy, A P F Turner, Cranfield University, UK and Linköping University, Sweden
- Introduction: cancer
- Breast cancer
- Human epidermal growth factor receptor 2 (2HER)
- The immunoassay
- Biosensors
- Problems with antibodies
- Affibodies
- References
Biosensors for drug testing and discovery
C Parsajoo and J-M Kauffmann, Université libre de Bruxelles, Belgium and M ElKaoutit Universidad de Cádiz, Spain
- Introduction
- Types of biosensor
- Optical biosensors
- Acoustic biosensors
- Conclusion
- Acknowledgments
- References
Biosensors for non-invasive measurements
L Micheli, D Moscone, and G Palleschi, University of Rome Tor Vergata and Consorzio Interuniversitario Biostrutture e Biosistemi INBB, Italy
- Introduction
- Biosensors for the detection of alcohol and lactate
- Detection using electrochemical and amperometric biosensors
- Detection using optical biosensors
- Conclusions
- References
Wearable biosensors for medical applications
C Crean, University of Surrey, UK, C McGeough, University of Ulster, UK and R O’Kennedy, Dublin City University, Ireland
- Introduction
- Background
- Considerations and requirements for wearable sensors
- Types of wearable sensors
- Temperature sensors
- Mechanical sensors
- Electrical sensors
- Biological and chemical sensing
- Clinical applications
- Future trends
- Sources of further information and advice
- References