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Sterilisation of tissues using ionising radiations

Edited by J F Kennedy, University of Birmingham, G O Phillips, Phillips Hydrocolloid Research Ltd and P A Williams, The North East Wales Institute, UK

Woodhead Publishing Series in Biomaterials No. 1

…a useful tool for tissue bankers, tissue recipients and donors as well as a supplement for transplant surgeons and students of medicine.
Carbohydrate Polymers

…provides detailed information.
Carbohydrate Polymers

 - high-quality papers highlighting the most recent developments in this important area
 - includes the full code of practice for the radiation sterilisation of tissues
 - edited by a highly respected team of experts

Existing methods and processing for sterilising tissues are proving inadequate in many instances. Infections have been transmitted from the graft to the recipient and in the USA the Centre for Disease Control and other regulatory bodies have drawn attention to the need for a reliable end sterilisation method which does not damage the functionality of the final tissue. Safety of surgical allografts is, therefore, a major concern due to microbial and viral contamination of tissues which is now a problem even in the most sophisticated centres.

The Presidents of the main Professional Association of Tissue Banks; American, European and Latin American met in Vienna to review the situation and concluded that the time was opportune to organise an international high level expert meeting, which would identify the best method of using radiation technology to assist in the production of safe tissue allografts

Sterilisation of biological tissues with ionising radiations provides the information on this subject presented at an international meeting in Wales, supported by the International Atomic Energy Agency. New methods of protecting the tissues were presented which at the same time allow the use of sufficiently high doses of ionising radiations to inactivate invading organisms. A Code of Practice for the Radiation Sterilisation of Tissues was evaluated and the outcome and the full Code is included in this volume, as well as explorations of all of the methodologies used in the field.

Sterilisation of biological tissues with ionising radiations is the only volume of its kind and as such is an invaluable source of information for those working in tissue banks, transplant surgeons and the safety regulators.

ISBN 1 85573 838 4
ISBN-13: 978 1 85573 838 6
May 2005
352 pages  244 x 172mm  hardback  
£175.00 / US$300.00 / €210.00

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About the editors

John F Kennedy is a director of Birmingham Carbohydrate and Protein Technology Group, University of Birmingham

Glyn O Phillips is the chairman of Research Transfer Ltd

Peter A Williams is a director of the Centre for Water Soluble Polymers.

Titles which may also be of interest:
Sterilisation of biomaterials and medical devices
Artificial cells, cell engineering and therapy
Surfaces and interfaces for biomaterials
Bioceramics and their clinical applications
Tissue engineering using ceramics and polymers
Biomaterials, artificial organs and tissue engineering

Contents

PART 1 STANDARDS FOR TISSUE BANKS AND FOR RADIATION STERILISATION OF TISSUES
PART 2 METHODOLOGY IN THE STERILISATION AND PRESERVATION OF TISSUES
PART 3 EFFECTS OF RADIATION ON BONE, TISSUES AND THEIR COMPONENTS
PART 4 VIRAL ASPECTS OF TISSUES FOR TRANSPLANTATION
PART 5 MICRBIOLOGICAL ASPECTS OF TISSUES FOR TRANSPLANTATION

PART 1 STANDARDS FOR TISSUE BANKS AND FOR RADIATION STERILISATION OF TISSUES

IAEA international standards for tissue banks

The development of a Code of Practice for the Radiation Sterilisation of Tissue Allografts

Use of the IAEA code of practice for the radiation sterilisation of bone allografts

PART 2 METHODOLOGY IN THE STERILISATION AND PRESERVATION OF TISSUES

Radiation sources: types and suitability for dose delivery to tissues for sterilisation

Improved method for gamma irradiation of donor tissue

Rapid heat transfer dynamics and cold gamma sterilisation methods for soft tissue allografts

Comparison of different thawing methods on cryopreserved rabbit aorta

PART 3 EFFECTS OF RADIATION ON BONE, TISSUES AND THEIR COMPONENTS

Effects of gamma irradiation on bone – clinical experience

Effects of gamma irradiation on the mechanical properties of human cortical allograft bone

The effect of cold gamma radiation sterilisation on the properties of demineralised bone matrix

Complications of structural allografts for malignant bone tumours

Effects of radiation on the integrity and functionality of soft tissue. Current situation: cartilage, heart valves, tendons and other tissues. Changes with increasing dose/dose limits

The effect of preservation procedures and radiation sterilisation conditions on connective tissue grafts and their constituents

Effects of radiation on the integrity and functionality of amnion and skin grafts

Structural effects of radiation sterilisation on sodium hyaluronate

PART 4 VIRAL ASPECTS OF TISSUES FOR TRANSPLANTATION

Viruses and their relevance for gamma irradiation sterilisation of allogenic tissue transplants

Viral infections transmitted through tissue transplantation

PART 5 MICRBIOLOGICAL ASPECTS OF TISSUES FOR TRANSPLANTATION

Bacterial inactivation in tissues

Novel pathogen inactivation of soft tissue allografts using optimised gamma irradiation

Establishing an appropriate terminal sterilisation dose based upon post-processing bioburden levels on allograft tissue

Determination of microbial bioburden levels on pre-processesd allograft tissues

Bioburden estimation in relation to tissue product quality and radiation dose validation

Protective effects on microorganisms in radiation sterilised tissues