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Food and cancer prevention: Chemical and biological aspectsK W Waldron, I T Johnson and G R Fenwick, Institute of Food Research, UK
Woodhead Publishing Series in Food Science, Technology and Nutrition No. 14
Food and cancer prevention: Chemical and biological aspects is the first book to be published on this subject and represents the current state-of-the-art. It is interdisciplinary in scope and provides researchers from around the world with the opportunity to bring themselves up-to-date in this vital area.
Food and cancer prevention: Chemical and biological aspects covers a topic which is attracting considerable attention and aims to promote constructive collaboration among clinicians, toxicologists, nutritionists, food scientists, epidemiologists and plant scientists worldwide. It is an essential reading for anyone involved in research in to this subject and will also be of interest to government departments, with a view to legislation, and food manufacturers producing functional, novel or health foods.
ISBN 1 85573 781 7
ISBN-13: 978 1 85573 781 5
January 1993
462 pages 234 x 156mm hardback
£180.00 / US$305.00 / €215.00

Reprinting – not in stock at present
Titles which may also be of interest:
Functional foods, ageing and degenerative disease
Functional foods, cardiovascular disease and diabetes
Phytochemical functional foods
Food diet and obesity
Contents
Part 1 The Relationships between Diet and Cancer in Human Populations
PART 2 THE OCCURRENCE AND SIGNIFICANCE OF CARCINOGENS IN FOODS
PART 3 FREE RADICAL REACTIONS AND ANTIOXIDANT NUTRIENTS IN THE ETIOLOGY OF HUMAN CANCERS
PART 4 TUMOUR INITIATION: THE SIGNIFICANCE OF ENDOGENOUS BIOTRANSFORMATION ENZYMES AND THEIR MODULATION BY DIET
PART 5 SUPPRESSING TUMOUR DEVELOPMENT: THE ROLE OF DIET IN THE MODULATION OF CELL PROLIFERATION
PART 6 IMMUNE MECHANISM: THE ROLE OF FOOD COMPONENTS AS IMMUNOREGULATORS
PART 7 DIETARY FIBRE AND RELATED SUBSTANCES
PART 8 RESEARCH TECHNIQUE: NEW APPROACHES
PART 9 IMPLICATIONS FOR PUBLIC HEALTH
Part 1 The Relationships between Diet and Cancer in Human Populations
Food: Its Role in the Etiology of Cancer
Gary M. Williams
Inhibition of Carcinogenesis by Nonnutrient Constituents of the Diet
Lee W. Wattenberg
Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and the Food Chain
James R. Startin
Contribution of Epidemiology in Elucidating the Role of Foods In Cancer Prevention
D. Kromhout, H.B. Bueno de Mesquita and M.G.L. Hertog
Diet and Mammographc Patterns: Work in Progress
Timothy Key, David Forman, Louise Cotton, Ann Lewis, Gwyneth Davey, John Moore, Graham Clark, Christine Mlynek, Joyce Tarrant, Philip Savage, Ruth English and Basil Shepstone
Workshop Report: New Developments in Epidemiology
W.P.T. James
PART 2 THE OCCURRENCE AND SIGNIFICANCE OF CARCINOGENS IN FOODS
Genotoxic Effects of Nitrosamines and Cooked Food Mutagens in Various Organs of Mice and Their Modification by Dietary Factors
S. Knasmüller, W. Parzefall, W. Huber, H. Kienzl and R. Schulte-Hermann
Influence of Sugar-Linked- and Diallyl-Dithiocarbamates on Mutagenic and Carcinogenic N-Nitroso Compounds
B. H. Lee, B. Bertram, P. Schmezer and M. Wiesler
In vitro Genetic Toxicology Testing of Naturally Occurring Isothiocyanates
S. R. R. Musk and I. T. Johnson
Possible Clastogenic and Anticlastogenic Actions of Fermented Milk “Narine”
A. K. Nersessian
Influence of Dietary Fat on Metabolism of 2-Amino-3-Methyl-3H-IMIDAZO[4,5-f]Quinoline (IQ)
C.J. Rumney, I.R. Rowland and I.K. O'Neill
Influence of Diet on the Conversion of 2-AMINO-3-METHYL-3H-IMIDAZO[4,5-f]Quinoline (IQ) to the 7-Keto Derivative (7-OHIQ)
C.J. Rumney and I.R. Rowland
Antimutagenic Action of Beta Carotene, Canthaxanthin and Extracts of Rosmarinus Officinalis and Melissa Officinalis. Genotoxicity of Basil and Tarragon Oil
Amalia Bianchi-Santamaria, Fernando Tateo and Leonida Santamaria
Nitrite-Free Meat Curing Systems and the N-Nitrosamine Problem
F. Shahidi and R.B. Pegg
Carbohydrates, Especially Mono- and Disaccharides in Excess Inhibit the Formation of Mutagenic Heterocyclic Amines During Frying of Meat
K. I. Skog and I. M. Jägerstad
Effects of Ellagic Acid, Tannic Acid and Quercetin on the Mutagenic Activity of Cooked Food Mutagens in the Salmonella Strain TA98
Michael Strube, Preben Aagaard Nielsen and John C. Larsen
Analysis of Human Sera for Aflatoxin
A.P. Wilkinson, D.W. Denning, H.A. Lee, C.M. Ward and M.R.A. Morgan
Workshop Report: Dietary Carcinogenesis - What Role in Human Cancer?
W. Jongen
PART 3 FREE RADICAL REACTIONS AND ANTIOXIDANT NUTRIENTS IN THE ETIOLOGY OF HUMAN CANCERS
Chemical Aspects and Biological Mechanisms of Anticancer Nutrients in Plant Foods
D. I. Thurnham
Antioxidant and Pro-Oxidant Actions of Dietary Components
O.I. Aruoma and B. Halliwell
In Vitro Antioxidant Activity of Lutein
M. Chopra and D. I. Thurnham
Effect of Vitamin A Dietary Intake on DNA Damage Induced in vitro by AFB1
S. Decoudu, P. Cassand, V. Colin, B. Koch and J.F. Narbonne
Availability of Soluble All-Trans Versus 9-CIS β-Carotene
G. Levin and S. Mokady
Effects of Dietary Anticarcinogens on Rat Hepatic and Intestinal Glutathione S-Transferases
W.A. Nijhoff and W.H.M. Peters
Quantitation of Provitamin-A and Non-Provitamin-A Carotenoids in the Fruits Most Commonly Consumed in Spain
B. Olmedilla, F. Granado, I. Blanco and E. Rojas-Hidalgo
Seasonal Variation of Serum Levels of β-Carotene and α-Tocopherol
M. Rautalahti, D. Albanes, J. Haukka, E. Roos and J. Virtamo
Antioxidant Vitamins or Lactulose as Chemopreventive Agents for Colorectal Cancer
L. Roncucci and M. Ponz de Leon
Carotenoids Plus Vitamin a in Cancer Prevention, Adjuvant Therapy, and Mastalgia Treatment (*)
Leonida Santamaria and Amalia Bianchi-Santamaria
Workshop Report: Role of Anti-Oxidants in Cancer Protection
D.G. Lindsay
PART 4 TUMOUR INITIATION: THE SIGNIFICANCE OF ENDOGENOUS BIOTRANSFORMATION ENZYMES AND THEIR MODULATION BY DIET
Modulation of Biotransformation Enzymes by Non-Nutritive Dietary Factors
Peter J. van Bladeren
Effect of Cooking and of Vegetables and Fruit On 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats
G. M. Alink, H. A. Kuiper, V. M. H. Hollanders and J. H. Koeman
Studies of Antimutagenic Factors in Food
G. Bronzetti, E. Morichetti, C. Salvadori and C. Della Croce
Does the Type of Fat Influence Intestinal and Hepatic Microsomal Metabolism?
R. Chinery, R. A. Goodlad, N. A. Wright and J. T. Borlak
Chemical and Biochemical Basis for Beneficial Effects of Sulfhydryl Compounds on Food Safety
Mendel Friedman
Determination of Potentially Anticarcinogenic Flavonoids in Foods and Preliminary Results on Daily Intake in the Netherlands
M.G.L. Hertog, P.C.H. Hollman and D. Kromhout
The Content of the Potentially Anticarcinogenic Ellagic Acid in Plant Foods
C.H. Peter Hollman and P. Dini Venema
Inhibitory Effect of an Extract of Leaves of Rosmarinus Officinalis L. on Tumor Initiation and Promotion in the Skin of CD-1 Mice
M-T. Huang, C-T. Ho, Z. Y. Wang, K. Stauber, C. Georgiadis, J.D. Laskin and A.H. Conney
Vitamin a as A Modulator of In vitro Unschedulded DNA Synthesis Induced by 2-AMINO-3-Methylimidazo[4,5-]Quinoline and 2-AMINO-3,4-Dimethylimidazo[4,5-]Quinoline in Rat Hepatocyte Primary Cultures
B. KOCH, S. BLOWERS, I. ROWLAND and J.F. NARBONNE
Comparison of Hydroxylated and Non-Hydroxylated Natural Flavonoids as In vitro Modulators of Rat Hepatic Benzo(a)Pyrene Metabolism
A.M. Le Bon, L. Ziegler and M. Suschetet
The Distribution of Quercetin and Quercetin Glycosides in Vegetable Components of The Human Diet
Terrance Leighton, Charles Ginther and Larry Fluss
In Vivo Studies on Antigenotoxic Effects of Na-Phytate and L. Casei in the Gastrointestinal Tract of Rats
B.L. Pool-Zobel, B. Bertram, K.D. Jany, U. Schlemmer and W.H. Holzapfel
Desmutagenic Effect of Vegetables on Mutagens and Carcinogens and Growth-inhibiting Effect of Spinach Components on Cultured Human Cancer Cells
K. Shinohara, M. Kobori and Z-L. Kong
Potential Anti-Mutagenicity and Anti-Carcinogenicity of Some Plant Phenols
R. Walker, A.D. Ayrton and C. Ioannides
Inhibition of Nitrosamine-Induced Tumorigenesis by Diallyl Sulfide and Tea
C. S. Yang, J-Y. Hong and Z.-Y. Wang
PART 5 SUPPRESSING TUMOUR DEVELOPMENT: THE ROLE OF DIET IN THE MODULATION OF CELL PROLIFERATION
Role of Dietary Factors in the Modulation of Cancer Induction
M. B. ROBERFROID
Diet and Breast Cancer
H Leon Bradlow, Nitin T Telang, Jon J Michnovicz and Michael P Osborne
Proliferative Activity in the Colon of Healthy Subjects in Two Italian Cities With Different Dietary Habits
Giovanna Caderni, Franca Bianchini and M.Teresa Spagnesi
Effects of Short Chain Fatty Acid Infusion on the Gastrointestinal Epithelium of Intravenously Fed Rats
RA Goodlad, R Chinery, CY Lee, MA Ghatei, SR Bloom and NA Wright
In vitro Studies Into the Selective Toxicity of Allyl Isothiocyanate Towards Transformed Human Tumour Cells
S. R. R. Musk and I. T. Johnson
Cancer Preventive Agents in Processed Garlic
Hoyoku Nishino
Omega 3 Fatty Acids Suppress Mucosal Crypt Cell Production in Rats
J.D. Pell, J.C. Brown and I.T. Johnson
Workshop Report: Increased Cell Proliferation as A Cause of Human Cancer
R. Goodlad
Workshop Report: Dietary Protective Factors - New Candidates
L. Wattenburg
PART 6 IMMUNE MECHANISM: THE ROLE OF FOOD COMPONENTS AS IMMUNOREGULATORS
Bioactive Cell Wall and Related Components From Herbal Products and Edible Plant Organs as Protective Factors
K. W. Waldron and R. R. Selvendran
Anti-Tumorigenic and Immunoactive Protein and Peptide Factors in Foodstuffs (I) - Anti-Tumorigenic Protein From Tricholoma Matsutake -
Y. Kawamura and M. Ishikawa
Anti-Tumorigenic and Immunoactive Protein and Peptide Factors in Foodstuffs (II)- Anti-Tumorigenic Factors in Rice Bran -
Y. Kawamura and M. Muramoto
PART 7 DIETARY FIBRE AND RELATED SUBSTANCES
Plant Cell Wall Material and Cancer Protection
S. A. Bingham
Lignans and Isoflavonoids of Dietary Origin and Hormone-Dependent Cancer
H. Adlercreutz, M. Carson, Y. Mousavi, A. Palotie, S. Booms, M. Loukovaara, T. Mäkelä, K. Wähälä, G. Brunow and T. Hase
Bile Acids in a Human Model of Colorectal Neoplasia
DM Bradburn, IR Rowland, JC Mathers, A Gunn, J Burn and IDA Johnston
Variations of Colonic Proliferation, Cecal and Fecal pH in Rats Fed Different Carbohydrates
Giovanna Caderni, Cristina Luceri and M. Teresa Spagnesi
Insoluble Dietary Fibre Rich Fractions From Barley Protect Rats From Intestinal Cancers
G.H. McIntosh, L. Jorgensen and P. Royle
Dietary Fibre and the Gastrointestinal Epithelium: Differential Response in the Stomach, Small Intestine and Colon of Conventional and Germ-Free Rats
B Ratcliffe, CY Lee, NA Wright and RA Goodlad
Influence of Dietary Fibers on Two Intestinal Transferases in Rats Inoculated With A Whole Human Faecal Flora
N. ROLAND, L. NUGON-BAUDON and O. SZYLIT
Nitrite-Binding Properties of Dietary Fibres
F. Shahidi and C. Hong
Workshop Report: Non-Starch Polysaccharides (NSP) and Colorectal Cancer: The Current Position
S. Bingham
PART 8 RESEARCH TECHNIQUE: NEW APPROACHES
Toxicological Methods to Study Mechanisms of Naturally Occurring Anticarcinogens
Wim.M.F. Jongen
Isolation and Identification of Putative Carcinogens and Anticarcinogens From Dietary and Faecal Samples by Supercritical Fluid Extraction and HPLC
A. D'Odorico, I.T. Gilmore, A. Morris, A.J. Young and R.F. Bilton
Cell Proliferation and Morphometry in Endoscopic Biopsies
RA Goodlad, S Levi, CY Lee and NA Wright
Detection of Abnormal Mucosal Cell Replication in Humans: A Simple Technique
J.A. Matthew, J.D. Pell, A. Prior, H.J. Kennedy, I.W. Fellows, J.M. Gee and I.T. Johnson
Rapid Detection of Inducers of Enzymes That Protect Against Carcinogens
Hans J. Prochaska, Annette B. Santamaria and Paul Talalay
Isolation and Identification of the Principal Inducer of Anticarcinogenic Protective Enzymes From Broccoli
Y. Zhang, P. Talalay, C.-G. Cho and G.H. Posner
Quantitation of Isothiocyanates by Cyclocondensation With 1, 2-Benzenedithiol
Y. Zhang, C.-G. Cho, G.H. Posner and P. Talalay
The Biological Assay of Natural Mutagens Using the P53 Gene
C. E. Couet, A. B. Hanley, S. Macdonald and L. Mayes
Workshop Report: Research Techniques - In Vivo Methodologies
Okezie I. Aruoma
Workshop Report: In Vitro Methodology
G. Williamson
PART 9 IMPLICATIONS FOR PUBLIC HEALTH
Implications for Dietary Guidance
W. P. T. James
