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MEMS for biomedical applications

Edited by S Bhansali and A Vasudev, Florida International University, USA

Woodhead Publishing Series in Biomaterials No. 43

 - reviews the wealth of recent research on fabrication technologies and applications of Micro Electro Mechanical Systems (MEMS) in the biomedical field
 - introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms
 - considers MEMS for biomedical sensing and diagnostic applications, along with MEMS for in vivo sensing and electrical impedance spectroscopy
 - discusses MEMS for tissue engineering and clinical applications and considers cell culture and tissue scaffolding devices

The application of Micro Electro Mechanical Systems (MEMS) in the biomedical field is leading to a new generation of medical devices. MEMS for biomedical applications reviews the wealth of recent research on fabrication technologies and applications of this exciting technology.

The book is divided into four parts: Part one introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms. Part two describes applications of MEMS for biomedical sensing and diagnostic applications. MEMS for in vivo sensing and electrical impedance spectroscopy are investigated, along with ultrasonic transducers, and lab-on-chip devices. MEMS for tissue engineering and clinical applications are the focus of part three, which considers cell culture and tissue scaffolding devices, BioMEMS for drug delivery and minimally invasive medical procedures. Finally, part four reviews emerging biomedical applications of MEMS, from implantable neuroprobes and ocular implants to cellular microinjection and hybrid MEMS.

With its distinguished editors and international team of expert contributors, MEMS for biomedical applications provides an authoritative review for scientists and manufacturers involved in the design and development of medical devices as well as clinicians using this important technology.

ISBN 0 85709 129 8
ISBN-13: 978 0 85709 129 1
July 2012
512 pages  234 x 156mm  hardback  
£155.00 / US$265.00 / €185.00

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About the editors

Shekhar Bhansali is the Alcatel-Lucent Professor and the Chair of the Department of Electrical and Computer Engineering at Florida International University, USA.

Abhay Vasudev is a Graduate Researcher at Florida International University’s bioMEMS and Microsystems Lab.

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Contents

PART 1 FUNDAMENTALS OF MEMS FOR BIOMEDICAL APPLICATIONS
PART 2 MEMS FOR BIOMEDICAL SENSING AND DIAGNOSTIC APPLICATIONS
PART 3 MEMS FOR TISSUE ENGINEERING AND CLINICAL APPLICATIONS
PART 4 EMERGING BIOMEDICAL APPLICATIONS OF MEMS

PART 1 FUNDAMENTALS OF MEMS FOR BIOMEDICAL APPLICATIONS

Microfabrication of polymers for bioMEMS
P Rezai, W I Wu and P R Selvaganapathy, McMaster University, Canada
 - Introduction  - Microfabrication
 - Polymers and processes
 - Conclusions
 - References

Review of sensor and actuator mechanisms for bioMEMS
P K Sekhar and V Uwizeye, School of Engineering and Computer Science, USA
 - Introduction: transducers
 - Sensors
 - Actuators
 - Biomedical applications of sensors and actuators
 - Optical biosensor
 - Microrobotics in biomedical applications
 - Conclusion
 - References

PART 2 MEMS FOR BIOMEDICAL SENSING AND DIAGNOSTIC APPLICATIONS

MEMS for in vivo sensing
S Aravamudhan, North Carolina A&T State University, USA
 - Introduction
 - Overview of MEMS in vivo devices and sensors
 - Challenges and possible solutions to in vivo sensing methodology
 - Regulatory dimensions
 - Conclusions and future trends
 - References

MEMS and electrical impedance spectroscopy (EIS) for non-invasive measurement of cells
D T Price, University of South Florida, USA
 - Importance of MEMS in cellular assays
 - Impedimetric measurement theory
 - Visualization and modelling
 - Bioimpedance before MEMS: Patch clamp measurements
 - MEMS in bioimpedance applications
 - Future trends
 - Sources of further information and advice
 - References

MEMS ultrasonic transducers for biomedical applications
R Guldiken and O Onen, University of South Florida, USA
 - Introduction
 - Modeling and design of capacitive micromachined ultrasonic transducers (CMUTs)
 - Fabrication
 - Integration
 - Biomedical applications
 - Conclusion and future trends
 - References

Lab-on-chip (LOC) devices and microfluidics for biomedical applications
K W Oh, University at Buffalo, The State University of New York (SUNY at Buffalo), USA
 - Introduction
 - Pressure-driven lab-on-chip (LOC)
 - Capillary-driven LOC
 - Electrokinetic-driven LOC
 - Centrifugal-driven LOC
 - Droplet-based LOC
 - Electrowetting-based LOC
 - Future trends
 - Sources of further information and advice
 - References

PART 3 MEMS FOR TISSUE ENGINEERING AND CLINICAL APPLICATIONS

Fabrication of cell culture microdevices for tissue engineering applications
J D Cuiffi, Draper Laboratory, USA
 - Introduction: Cell culture microdevices
 - Motivation for microdevice development
 - Design and fabrication concepts for cell culture
 - Applications of cell culture microdevices
 - Future trends
 - Sources of further information and advice
 - References

MEMS manufacturing techniques for tissue scaffolding devices
C-W Li and G-J Wang, National Chung-Hsing University, Taiwan
 - Introduction
 - Tissue scaffold design
 - Tissue scaffold fabrication using MEMS approaches
 - Applications of MEMS fabricated tissue scaffold
 - Conclusion
 - References

BioMEMS for drug delivery applications
L Kulinsky and M J Madou, University of California, Irvine, USA
 - Introduction
 - Transdermal delivery
 - Implantable systems
 - Microfabricated drug delivery vehicles
 - Conclusions
 - Acknowledgement
 - References

Applications of MEMS technologies for minimally invasive medical procedures
K Oldham, University of Michigan, USA
 - Introduction
 - Micro-visualization
 - Micro-manipulation
 - Future trends and conclusions
 - References

Smart Microgrippers for bioMEMS applications
Y Q Fu, University of the West of Scotland, J K Luo, University of Bolton, A J Flewitt, W I Milne, University of Cambridge, UK
 - Introduction
 - Microgripping and release strategies: microgripping techniques
 - Microgripping and release strategies: releasing techniques
 - Microgripper demonstration: microcage
 - Conclusions
 - Acknowledgement
 - References

Microfluidic techniques for the detection, manipulation and isolation of rare cells
R V Davalos and M B Sano, Virginia Tech – Wake Forest School of Biomedical Engineering, USA
 - Introduction
 - Sized-based isolation
 - Mass-based isolation
 - Electrical-based isolation
 - References

PART 4 EMERGING BIOMEDICAL APPLICATIONS OF MEMS

MEMS as implantable neuroprobes
A V Govindarajan, W-T Park, Seoul National University of Science and Technology, Korea, M Je, Institute of Microelectronics, Singapore; A H Achyuta, The Charles Stark Draper Laboratories, USA
 - Introduction: neuronal communication
 - MEMS-based neuronal intervention devices
 - Tissue response against implanted neural microelectrode interfaces
 - Implantable wireless recording integrated circuit (IC) challenges
 - References

MEMS as ocular implants
W Li, Michigan State University, USA
 - Introduction
 - Implantable MEMS for glaucoma therapy
 - Integrated microsystems for artificial retinal implants
 - Future trends
 - Conclusion
 - References

Cellular microinjection for therapeutics and research applications
P Khanna, Globalfoundries, USA
 - Introduction
 - Significance of cellular injection
 - Microinjection
 - MEMS technologies for microinjection
 - Future of mechanical microinjection
 - Automating microinjection
 - Conclusion
 - References

Hybrid MEMS: Integrating inorganic structures into live organisms
A J Shum and BA Parviz, University of Washington, USA
 - Introduction
 - Hybrid integration
 - Vacuum microfabrication on Drosophila
 - Conclusions and future trends
 - References