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Allergic diseases and the environment (Volume 53) (Nestlé nutrition workshop series: Pediatric program)
Edited by E Isoluri and W A Walker
During the last two decades the increase in allergic diseases in children, such as atopic dermatitis and asthma, has been drastic. However, this is not true for the entire world: the incidence of allergies in children has risen only in developed countries. The observation of this socio-geographic discrepancy has led to careful study of the environmental differences that exist between the diverse settings in which children are born and has resulted in the so-called ‘hygiene hypothesis’: the ‘sterility’ of modern hospitals and birth places in the developed world might lead to a lack of microbial stimulation required for the development of a balanced mucosal immune response, including expansion of T-helper (Th) cell subsets that can mediate immune responses. Therefore, this workshop was held to consider in depth the environmental factors that influence the changing pattern of worldwide childhood allergy.
This publication is a valuable source of knowledge and update for nutritionists, pediatricians, immunologists, microbiologists, as well as professionals concerned with preventive medicine.
ISBN 3 8055 7649 8
ISBN-13: 978 3 8055 7649 9
June 2004
324 pages 234 x 156mm hardback
£120.00 / US$205.00 / €150.00
Usually dispatched within 1–2 weeks
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Contents
Clinical overview: The changing pattern of clinical aspects of allergic diseases; Changing definitions of allergy; The changing prevalence and clinical profile of food allergy in infancy; The hygiene hypothesis: Modulation of the atopic phenotype by environmental microbial exposure; Allergy: Is it a Th2-predominant disease? Pro; The induction of immunoregulation prevents the development of immunopathology in chronic helminth infections and allergy; Mechanisms governing non-responsiveness to food proteins; Oral tolerance and gut maturation; The role of bacteria in the development of intestinal protective function; Human colonic microbes: Ecology, physiology and metabolic potential of intestinal bacteria; Does breast-feeding protect from allergies? Protective nutrients and gastrointestinal allergies; Identification of probiotics and prebiotics with antiallergenic properties; Can we prevent the allergic child from becoming a chronic asthmatic adult? The German infant nutritional intervention study (GINI): A model for allergy prevention; Novel approaches for the nutritional management of the allergic infant.