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Bioactive lipidsEdited by A Nicolaou, University of Bradford, UK and G Kokotos, University of Athens, Greece
Oily Press Lipid Library Series No. 17
…this is an excellent book that deserves to sell well. It should be on the desk of everyone with any interest in lipids.
Lipid Technology
Overall, the book represents a much-needed reference for those of us who are actively engaged in researching the generation of bioactive lipids in health and disease. The information collates much of what is known about this class of molecules in a straightforward and easy-to-follow manner and the book will be a very useful addition to the library of lipid researchers.
The Biochemist
An impressive international team of authors address the various aspects - nomenclature and structure, biochemistry, pharmacology and recent developments - in the main classes of lipids.
Oils and Fats International
In Bioactive lipids, Anna Nicolaou and George Kokotos have brought together an international team of authors to discuss the nomenclature, structures, biochemistry, pharmacology and recent developments in the main classes of bioactive lipids. These lipids are essential components of the cell membrane and play many dynamic roles in mediating and controlling a wide array of cellular activities including membrane structure and organization, metabolic and gene regulation, protein structure and function, energy production, and signalling pathways.
The lipid interests of scientists in the pharmaceutical and food industries are converging as the broader significance of bioactive lipids is increasingly recognized. Lipids and lipid-metabolizing enzymes are targeted for the development of new drugs. Meanwhile, functional foods, nutraceuticals and supplements already have lipids as major active ingredients. The food industry will progress from simply using lipids as ingredients, to the formulation of products that influence the synthesis, metabolism and effects of bioactive lipids in the body. These advances in applied lipid biochemistry will build on the fundamental research of lipid scientists in universities worldwide, such as those scientists contributing to Bioactive lipids.
ISBN 0 9531949 7 3
ISBN-13: 978 0 9531949 7 1
September 2004
314 pages 234 x 156mm hardback
£130.00 / US$220.00 / €155.00
Usually dispatched within 24 hours
About the editors
Anna Nicolaou, University of Bradford, UK.
George Kokotos, University of Athens, Greece.
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Contents
Fatty acids
Philip C. Calder and Graham C. Burdge
- Introduction
- Fatty acids – structure and nomenclature
- Fatty acid biosynthesis
- Lipid digestion, absorption and transport in the bloodstream and delivery to tissues
- The roles of fatty acids
- Fatty acids – nutritional aspects
- Fatty acids and human health
- Concluding remarks
- References
Diacylglycerols
Kevin P. Becker and Yusuf A. Hannun
- Introduction
- Glycerolipids
- Formation of diacylglycerol during intermediary lipid metabolism
- Regulated diacylglycerol metabolism
- Diacylglycerols
- Cellular targets of diacylglycerol
- Role of diacylglycerol in normal cellular physiology
- Role of diacylglycerol in pathophysiology
- Tools for analysis
- Monoacylglycerols
- Alkylacylglycerols
- Unanswered questions
- Concluding remarks
- Acknowledgements
- References
Phosphoinositides
Bernard Payrastre
- Introduction
- Biochemistry
- Localization of the various phosphoinositides
- Functions of phosphoinositides
- Phosphoinositides and human diseases
- Concluding remarks
- References
Lysolipids: Sphingosine 1-phosphate and lysophosphatidic acid
Susan Pyne
- Introduction
- Sphingosine 1-phosphate (S1P)
- Lysophosphatidic acid (LPA)
- Signalling of S1P and LPA
- Recent advances in therapeutics
- Concluding remarks
- References
Plasmalogens, platelet-activating factor, and other ether glycerophospholipids
Akhlaq A. Farooqui and Lloyd A. Horrocks
- Introduction
- Plasmalogens
- Platelet-activating factor (PAF)
- Anti-tumor ether lipids
- Other ether lipids
- Involvement of plasmalogens, platelet-activating factor, and other ether lipids in diseases
- Concluding remarks
- Acknowledgment
- References
Ceramides
Silvia Vaena de Avalos, Jeffrey A. Jones and Yusuf A. Hannun
- Introduction
- Metabolism
- Experimental approaches and tools to probe for intracellular roles of ceramide
- Molecular mechanisms of ceramide action
- Recent advances in understanding ceramide-regulated responses
- Concluding remarks
- Acknowledgements
- References
Glycosphingolipids
Thomas Kolter
- Introduction
- Nomenclature and structures
- Chemical synthesis of glycosphingolipids and analogues
- Function
- Biosynthesis
- Degradation
- Concluding remarks
- References
Prostanoids
Anna Nicolaou
- Introduction
- Nomenclature and structures of prostanoids
- Biosynthesis of prostanoids
- Mechanisms of prostanoid action
- Biological activity and therapeutic applications
- Analytical methodologies for prostanoid detection
- Concluding remarks
- References
Leukotrienes and lipoxins
Stefano Fiore
- Introduction
- Biosynthetic pathways
- The leukotrienes
- Lipoxins
- Biological interfaces
- Determination of leukotrienes and lipoxins in biological samples
- Concluding remarks
- References
Endocannabinoids
George Kokotos
- Introduction
- Milestones in cannabinoid research
- Cannabinoid receptors
- Endocannabinoids and related fatty acid amides
- Biosynthesis and metabolism
- The endocannabinoid system as a target for the development of novel therapeutic agents
- Concluding remarks
- References
Isoprostanes
Samar Basu
- Introduction
- Biosynthesis and occurrence
- Metabolism and excretion
- Isoprostanes as indicators of oxidant stress
- Analytical methodologies
- Pharmacological actions
- Isoprostanes in human studies
- Isoprostanes as markers of lipid oxidation
- Concluding remarks
- References