This item is in: Materials > Biomaterials > Applications

Inhaler devices: Fundamentals, design and drug delivery

Edited by P Prokopovich, University of Cardiff, UK

Woodhead Publishing Series in Biomaterials No. 59

 - introduces the fundamentals of inhaler technology
 - discusses the history of inhalers as well as current research and development as well as possible future trends
 - considers the development of inhaler devices, drug formulations and discusses the treatment of asthma
 - as essential design guide for good industrial practice
 - an invaluable resource for those researching and treating conditions such as asthma as well as those developing and manufacturing inhalation devices

Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development.

Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends.

Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices.

ISBN 0 85709 496 3
ISBN-13: 978 0 85709 496 4
April 2013
192 pages  234 x 156mm  hardback  
£120.00 / US$205.00 / €145.00

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About the editor

Dr Polina Prokopovich is a Cardiff Academic Fellow in the School of Pharmacy and Pharmaceutical Sciences and School of Engineering at Cardiff University, Wales, UK and she is a Visiting Academic Fellow in the Center for Biomedical Engineering of Massachusetts Institute of Technology, Cambridge, MA, USA. She has an international reputation for her research in the area of biomaterials and biotribology, particularly the development of novel biomedical materials with functional properties.

Titles which may also be of interest:
Drug-device combination products
Surfaces and interfaces for biomaterials
Biosensors for medical applications

Contents

PART 1 FUNDAMENTALS AND CONSIDERATIONS OF INHALER DEVICES
PART 2 DRUG FORMULATIONS FOR INHALER DEVICES

PART 1 FUNDAMENTALS AND CONSIDERATIONS OF INHALER DEVICES

Anatomy and pathophysiology of the respiratory system
E Callard Preedy and P Prokopovich, Cardiff University, UK
 - Introduction
 - Functional anatomy
 - Pathophysiology
 - Analysis of pathophysiology
 - References

History of inhaler devices
E Callard Preedy and P Prokopovich, Cardiff University, UK
 - Introduction
 - Structure and function of the lungs
 - Inhalers and successful therapy
 - Nebulisers
 - Pressurised metered-dose inhalers (pMDIs)
 - Dry powder inhalers
 - Future trends
 - References

Tribology of inhaler devices and components
P Prokopovich, Cardiff University, UK
 - Introduction
 - Design and principles of pressurised metered-dose inhalers (pMDIs)
 - Friction and lubrication within inhaler devices
 - Measuring friction between pMDI components
 - References

Novel coatings and biotechnology trends in inhaler devices
E Callard Preedy and P Prokopovich, Cardiff University, UK
 - Introduction
 - Current trends in inhaler devices
 - Novel coatings
 - Biotechnology
 - References

Microbial control and safety in inhalation devices
S Perni, University of Birmingham, UK
 - Microbial cells
 - Growth of microorganisms in the environment
 - Microbial inactivation
 - Microbial contamination control
 - Keeping inhalers microbiologically safe
 - References

PART 2 DRUG FORMULATIONS FOR INHALER DEVICES

Chitosan and inhalers: a bioadhesive polymer for pulmonary drug delivery
R Harris, N Acosta, A Heras, Complutense University of Madrid, Spain
 - Introduction
 - Chitosan based inhaler drug delivery systems
 - The absorption enhancing effect of chitosan
 - Types of particle systems used in inhalers
 - Inhaler formulations based on chitosan and chitosan derivatives
 - Conclusions
 - References

Polyelectrolyte assemblies for drug storage and delivery: Multilayers, nanocapsules, and multicapsules
E Guzmán, National Research Council, Italy, M Ruano, R G Rubio and F Ortega, Complutense University of Madrid, Spain
 - Introduction
 - Layer-by-layer (LbL) multilayers for drug delivery applications: planar polyelectrolyte multilayers (PEMs) and capsules
 - Assembling of Layer-by-layer (LbL) multilayers
 - Variables affecting the electrostatic self-assembling
 - Properties of polyelectrolyte multilayers interest in drug delivery
 - Encapsulation approximations
 - Encapsulating bioactive molecules
 - Strategies for releasing encapsulated drugs
 - Layer-by-layer (LbL) capsules in drug delivery applications
 - Layer-by-layer (LbL) capsules and inhalers
 - Conclusions
 - Acknowledgements
 - References

Functionalized core-shell nanoparticles for medical applications
E Mileva and B Soklev, Bulgarian Academy of Sciences, Bulgaria, V Michailova, Medical University, Bulgaria, and D Arabadzhieva, Bulgarian Academy of Sciences, Bulgaria
 - Introduction
 - New insights into copolymer NSAID interactions
 - Materials and methods of interfacial and bulk studies of copolymer drug aqueous systems
 - Experimental results and implications for intake and release mechanisms
 - Conclusions
 - Acknowledgements
 - References